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Guardant Health

Developing technology that aims to transform cancer to a preventable and manageable disease.

Systems Engineer
Redwood City, CA, US
Job Description / Skills Required


We believe conquering cancer is a big data problem. That’s why we built the world’s leading comprehensive liquid biopsy. This non-invasive tool for accessing and sequencing tumor DNA is used by thousands of oncologists to help tens of thousands of advanced cancer patients. We believe the boom in cancer data acquisition we helped launch will drive important discoveries and new products. We’re working on some exciting ones, including in early detection, where the impact on patients can be profound. We’ve raised more than $500 million from investors including Sequoia Capital, Khosla Ventures, OrbiMed, and SoftBank.
Job Description

In this role, you’ll be part of a team that is responsible for automating and scaling complex workflows and implementing processes for a state of the art sequencing lab. You will wear multiple hats and support the development of all parts of a state of the art robotics facility. Your customers will be licensed clinical operators; your goal is to use software and automation to help them focus on extensive screening.

The Systems Engineer will focus on developing, validating and sustaining integration interfaces between lab instrumentation and software systems. This includes defining complex calculations, data import/export, and custom scripts.

As a Systems Engineer, you must be collaborative and able to effectively participate in or lead cross functional teams working in a variety of projects. These cross functional teams will explore, develop, optimize, test, and implement robust, scalable solutions for Guardant Health’s sample processing workflows with attention to understanding business and user requirements and improving efficiency, throughput, and quality.

You will be expected, after training, to understand, and to perform all laboratory procedures needed to process samples with our workflows to support process development and implementation activities.

Essential Duties and Responsibilities:

Maintain and develop software and Excel-based tools used by Clinical Laboratory Scientists to manage processing information and prepare robotic worklists.
Gather requirements, write specifications, and develop test procedures to validate software tools used in the clinical laboratory.
Review and author documentation per regulatory standards.
Analyze workflows, identify bottlenecks, and develop solutions to improve efficiency, throughput, cost, and quality.
Contribute to innovation of current and new assays workflows, technologies and processes.


A BS degree in engineering or science, preferably in molecular biology, genetics or biochemistry, bioengineering, chemical engineering or a closely-related discipline and a minimum of 3 years of related industry experience.
Minimum 2 years experience implementing Excel worksheets, containing complex formulas and VBScript macro functions.
Minimum 2 years experience creating, modifying, and managing code written in scripting languages such as VBScript, Python, Perl, Javascript, R or similar.
Must possess a solid understanding of Windows OS, Mac OSX, and Linux in a mixed enterprise environment.
Experience with troubleshooting technical computer hardware, software, and networking problems.
Experience interfacing off-the-shelf instrumentation with vendor-supplied API’s is a plus.
Experience interfacing off-the-shelf hardware using RS-232 protocols is a plus.
Experience with operating and programming liquid handling robotics platforms (Hamilton, TECAN, Beckman, Agilent) is a plus.
Experience with standard molecular biology techniques such as nucleic acid isolation, purification and quantitation, bioanalyzer, DNA/RNA quantitation, qPCR or next generation sequencing is a plus.
Experience communicating and collaborating with internal and external colleagues and customers from diverse scientific, engineering, operational, and regulatory disciplines
Familiarity with querying relational databases using SQL is a plus.
Experience analyzing and debugging code.
Familiarity with the Software Development Lifecycle concepts, configuration management, source code control, and deployment strategies in a production environment.
Strong Documentation skills
Experience writing user requirements, functional specifications, validation plans, and other technical guidelines regarding hardware or software configuration.
Ability to create process flow diagrams.

Additional Information

All your information will be kept confidential according to EEO guidelines.